Nanoparticles, Nanobots and Bio Cyber Interface

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Lisa McGee’s (VaxxChoice) report on Nanoparticles, Nanobots and Bio Cyber Interface.

Read, research on your own, ask questions, share and discuss with others, become fearless and take action to make change. These substacks are informative and calls to action:

Synthetic biology “applications” have infiltrated and strategically influenced the energy and environmental ecosystems. Synthetic microbes produce and facilitate biofuels efficiently, or even break down plastics into reusable components. The intended goal to create a world where waste is feedstock for new materials, powered by organisms designed from scratch. Or take the organic biology system, introduce and infiltrate it with synthetic material; one of the most invasive being pharmaceuticals. Pharmaceuticals are an equation of corrosive chemical compounds, and synthetic hybrid bacterium. And ALL are trafficked by way of medicines, drugs, devices, and of course the ferris wheel machine that we know as vaccines and patented viruses/pathogens. What is extremely important to understand is this: vaccines and bio engineered pathogens (viruses) are one and the same.

By 2030 or beyond, expect synthetic biology to be a cornerstone of a bioeconomy, where DNA is as programmable as code. The pace depends on breakthroughs in automation, AI-driven design (like protein-folding models), and public acceptance. It’s not sci-fi anymore, it’s a toolkit reshaping life itself.

And ALL this contributes to the “transmutation” to humanity operating, and functions as a environment of synthetic biology.

Each of these systems: Nanoparticles, Nanobots and Bio Cyber Interface are components of a massive machine/matrixthat operates as a global operation, facilitated and manned by governments, their militaries and agencies, pharmaceutical companies, chemical chemicals, universities, public and private organizations, and several tech companies. Third party contractors assist in the overall operations as well.

Indvidiually, each of these systems, stand-alone within their architectural design. They are each multilayered in purpose and functionality; and are programmed/coded to collaborate within their responsibilities. The architectural operations of these coded systems are designed with extremely detailed military grade repsonsibilites and perform their duties with military grade accuracy and precision. These systems are delivered (trafficked) many ways; pharmaceuticals, specifically vaccines and synthetic bacterium (patented viruses) are the preferred method.

Bacterium based “causative agents” (which is the official terminology) are primed with ALL of these systems. These causative agents make up the elaborate apparatus of synthetic biology.

Nanoparticles

Nanoparticles are referred to as tiny particles, typically on the nanoscale (1-100 nanometers), that are tagged with unique identifier - often DNA sequences, peptides, or other molecular markers, and act as "barcodes." These barcodes facilitate the ability to track, identify, and analyze the nanoparticles' behavior, distribution, or efficacy in various applications, particularly in biomedical research and drug delivery.

DNA is a popular choice for barcoding due to its vast coding capacity (e.g., an 8-nucleotide sequence can yield 65,536 unique combinations) and compatibility with high-throughput sequencing technologies. In drug delivery studies, nanoparticles can be loaded with therapeutic agents and paired with distinct DNA barcodes. These particles are then introduced into a biological system and their distribution across organs or cells is tracked by sequencing the barcodes. This enables researchers and others to test hundreds or even thousands of nanoparticle formulations simultaneously in vivo, drastically reducing the time and number of subjects needed compared to traditional methods. *Additionally, these systems facilitate the collection of the biological system’s data

Other barcoding methods exist too, like isotopic tags or phase-change nanoparticles with unique melting points, but DNA stands out for its precision and scalability. The technique has shown promise in optimizing nanoparticle design for targeted therapies; think cancer drugs hitting tumors without affecting healthy tissue - by revealing which particles reach their intended destinations most effectively. This is an orchestrated operational fusion of nanotechnology and molecular biology, pushing the boundaries of personalized medicine and beyond.

Nanodevices

A nanodevice is a tiny machine or mechanism built on the nanoscale, typically measured in nanometers (one billionth of a meter). These devices are often constructed using nanotechnology, which involves manipulating matter at the atomic or molecular level. Nanodevices can take many forms, such as nanoscale robots (nanobots), sensors, actuators, or electronic components, and they’re designed to perform specific tasks. Because of their small size, nanodevices can interact with biological systems, materials, or environments in unique ways. For example, in medicine, they might deliver drugs directly to cells or detect diseases at an early stage. In electronics, they could be used to create ultra-small circuits or improve energy efficiency. The concept often bridges physics, chemistry, biology, and engineering, making it a pretty interdisciplinary field.

Nanobots

Nanobots, short for nanorobots, are tiny machines designed to perform specific tasks at the nanoscale, which is about 1 to 100 nanometers (a nanometer is one-billionth of a meter). These microscopic robots are typically built using advanced nanotechnology, combining engineering, physics, chemistry, and biology. The concept of nanobots stems from the idea of manipulating matter at the atomic or molecular level to create devices capable of precise functions.

Nanobots are envisioned as programmable machines that could operate inside the human body, in the environment, or in industrial settings. *Nanobots could self-replicate, communicate with each other, and execute complex tasks collaboratively, guided by internal programming or external signals.

The idea was popularized by scientists like Eric Drexler in the 1980s, who imagined "molecular assemblers" that could build anything atom by atom. Nanotechnology has produced nanoparticles and simple nanoscale devices - like sensors or drug-delivery systems. Current research focuses on materials like carbon nanotubes, DNA-based structures, or synthetic polymers to create these tiny systems. Challenges include powering them (often using chemical reactions or external energy like ultrasound), ensuring they’re safe (e.g., biocompatible in humans), and controlling them precisely.

*Evidence proves these are not biocompatible to biological systems

Nanobots in pharmaceuticals

Nanobots in pharmaceuticals represent one of the most promising and actively researched applications of nanotechnology. The core idea is to use these tiny, programmable machines to enhance drug delivery, diagnostics, and treatment at a cellular or even molecular level. Here’s how they’re shaping up in the field:

Drug Delivery
Nanobots have revolutionize how medicines are administered by targeting specific sites in the body with precision. Nanobots engineered to carry payloads of drugs (e.g., chemotherapeutic agents) and release them only at the intended location, such as a tumor. They might navigate the bloodstream, recognize diseased cells via surface markers (like proteins unique to cancer), and deploy their cargo on command. Research has already produced nanoparticle-based systems, examples such as liposomes or gold nanoparticles that do this passively. “Active” nanobots with onboard decision-making (e.g., responding to pH or temperature changes) are the next goal.

Diagnostics
Beyond delivery, nanobots act as diagnostic tools. Imagine them circulating through your body, equipped with sensors to detect abnormalities like inflammation, infection, or early-stage disease long before symptoms appear. They could signal findings to external devices or trigger a therapeutic response themselves. *Experimental nanosensors made from carbon nanotubes or quantum dots can already detect glucose levels or specific biomolecules.

Tissue Repair and Regeneration
In pharmaceuticals, nanobots could go beyond delivering drugs to actively repairing damage. Nanobot/nanosensors canplaque from arteries, stitching together damaged cell membranes, or stimulating tissue regrowth by releasing growth factors.

DNA-based nanorobots shows they can perform simple tasks, like sorting molecules or triggering reactions inside living cells.

Real-World Progress.
*Lipid nanoparticles: Used in mRNA COVID-19 vaccines (Pfizer, Moderna) to deliver genetic instructions into cells.

*DNA nanorobots: In 2018, researchers demonstrated DNA-based bots that could identify and attack cancer cells in mice by cutting off their blood supply.

*Magnetic nanoparticles: Guided by external magnetic fields, these have been tested to deliver drugs to specific brain regions.

Molecular assemblers: molecular machines performing chemical synthesis

Molecular assemblers were proposed by K. Eric Drexler in 1986, based on the ideas of R. Feynman. In his (quite lurid) book “Engines of Creation: The Coming Era of Nanotechnology” and follow-up publications Drexler proposes molecular machines capable of positioning reactive molecules with atomic precision and to build larger, more sophisticated structures via mechanosynthesis.

Natural paragons

Ribosomes, non-ribosomal peptide synthases (NRPSs) and polyketide synthetases (PKSs) are molecular assemblers that perform atomically precise movements along a cascade of events. Ribosomes are the most sophisticated, programmable assemblers, and probably far beyond of what we could ever achieve as chemists. NRPSs are still complex, but their mechanisms are suitable as paragons for artificial systems.

https://pmc.ncbi.nlm.nih.gov/articles/PMC8163427/

A molecular assembler that produces polymers

Molecular nanotechnology development is advanced, and the development synthetic molecular machines is real. nanotechnology is systems able to achieve the assembly-line like production of molecules such as discovery of a rudimentary synthetic molecular assembler that produces polymers. The molecular assembler is a supramolecular aggregate of bifunctional surfactants produced by the reaction of two phase-separated reactants. Initially self-reproduction of the bifunctional surfactants is observed, but once it reaches a critical concentration the assembler starts to produce polymers instead of supramolecular aggregates. The polymer size can be controlled by adjusting temperature, reaction time, or introducing a capping agent

https://www.nature.com/articles/s41467-020-17814-0

Bio Cyber Interface

A bio-cyber interface, often referred to as a brain-computer interface (BCI) or neural interface, is a system that enables direct communication between a biological entity (typically a human or animal brain) and an external electronic or computational device. It bridges the gap between biological processes (like neural signals) and cybernetic systems (computers or machines), allowing for the exchange of information without the need for traditional physical input methods like keyboards or voice commands.

How It Works
The interface typically involves:

1. Signal Acquisition: Sensors detect electrical activity in the brain (e.g., via electroencephalography (EEG), implanted electrodes, or other neuroimaging techniques).

2. Signal Processing: The raw biological signals are translated into digital data that a computer can understand, often using algorithms to filter noise and identify patterns.

3. Output: The processed data is used to control devices (e.g., a robotic arm, a cursor on a screen) or to send information back to the brain (e.g., sensory feedback).

Applications
*Medical: Helping people with disabilities (e.g., controlling prosthetic limbs or wheelchairs for those with paralysis).

*Military: Enhancing soldier performance or controlling drones remotely.

*Research: Studying brain function and cognition.

*Future Potential: Merging human cognition with artificial intelligence, as explored by companies like Neuralink.

In essence, a bio-cyber interface represents a fusion of biology and technology, aiming to augment or restore human capabilities or even redefine how we interact with the digital world. Bio-cyber interfaces are used for tracking and tracing biological processes, such as monitoring drug delivery and health parameters. These interfaces focus on status tracking rather than physical location, given their nanoscale applications.

Bio-cyber interfaces are technologies that connect biological systems with digital systems, and they are used for tracking and tracing, especially in monitoring biological processes inside the body. These interfaces are often part of the Internet of Bio-Nano Things (IoBNT), where nanoscale devices monitor and control activities like drug delivery or health metrics. This technology facilitates the connection between biological entities and cybernetic systems, enabling monitoring and control of biological processes at a nanoscale level.

They can track where a drug is delivered in the body or monitor vital signs over time, which fits the idea of tracing the status of treatments. However, they typically don't track physical locations like GPS does, as they're more about monitoring biological states at a microscopic level. This is particularly useful in healthcare, such as ensuring drugs reach the right organ or tracking the progress of therapies. An unexpected detail is that while "track and trace" is common in logistics, here it applies to biological systems, showing a broader application of the term.

Understanding Bio-Cyber Interfaces
Bio cyber interface is closely related / tethered to "cyberbiosecurity." Cyberbiosecurity is described as a discipline at the intersection of cybersecurity, cyber-physical security, and biosecurity, aiming to safeguard the bioeconomy Cyberbiosecurity

Wikipedia https://en.wikipedia.org/wiki/Cyberbiosecurity

Cyberbiosecurity in the new normal: Cyberbio risks, pre-emptive security, and the global governance of bioinformation

The Covid-19 pandemic saw a surge in cyber-attacks targeting pharmaceutical companies and research organizations working on vaccines and treatments for the virus. Such attacks raised concerns around the (in)security of bioinformation (e.g. genomic data, epidemiological data, biomedical data, and health data) and the potential cyberbio risks resulting from stealing, compromising, or exploiting it in hostile cyber operations. This article critically investigates threat discourses around bioinformation as presented in the newly emerging field of ‘cyberbiosecurity’. As introduced by scholarly literature in life sciences, cyberbiosecurity aims to understand and address cyber risks engendered by the digitisation of biology.

https://www.cambridge.org/core/journals/european-journal-of-international-security/article/cyberbiosecurity-in-the-new-normal-cyberbio-risks-preemptive-security-and-the-global-governance-of-bioinformation/625CE08933DE3C0AE3ECBAF4698551A2#

Biologically Inspired Bio-Cyber Interface Architecture and Model for Internet of Bio-NanoThings Applications.

More specifically, bio-cyber interfaces are integral to IoBNT, a network of nanoscale and biological devices communicating via molecular means, often for applications in healthcare, such as continuous health monitoring and targeted drug delivery.

https://www.researchgate.net/publication/304338576_Biologically_Inspired_Bio-Cyber_Interface_Architecture_and_Model_for_Internet_of_Bio-NanoThings_Applications

Track and Trace -
In the context of bio-cyber interfaces, track and trace extends to monitoring biological processes or the status of nanodevices within the body. For instance, targeted drug delivery involves tracking where drugs are delivered and how they are metabolized, while continuous health monitoring tracks vital signs over time

A Systematic Review of Bio-Cyber Interface Technologies and Security Issues for Internet of Bio-Nano https://www.researchgate.net/publication/353037619_A_Systematic_Review_of_Bio-Cyber_Interface_Technologies_and_Security_Issues_for_Internet_of_Bio-Nano_Things

Applications and Evidence

Biologically Inspired Bio-Cyber Interface Architecture and Model for Internet of Bio-NanoThings Applications
The applications of bio-cyber interfaces, include healthcare settings like intra-body sensing, targeted drug delivery, and nano-surgeries. A model for IoBNT applications, focusing on monitoring and controlling nanodevices, which inherently involves tracking their activities.

https://www.researchgate.net/publication/304338576_Biologically_Inspired_Bio-Cyber_Interface_Architecture_and_Model_for_Internet_of_Bio-NanoThings_Applications

CRISPR-Enabled Graphene-Based Bio-Cyber Interface Model for In Vivo Monitoring of Non-Invasive Therapeutic Processes

Another study by Chude-Okonkwo et al. (2024) discusses a CRISPR-enabled model for in vivo monitoring of therapeutic processes, suggesting tracking of treatment progress.

https://pubmed.ncbi.nlm.nih.gov/38157459/

Internet of Bio Nano Things-based FRET nanocommunications for eHealth

The functionality of track and trace (surveillance) is evident. For instance, in targeted drug delivery systems, bio-cyber interfaces monitor drug transmission to reduce side effects, effectively tracing the drug's path. Continuous health monitoring, another application, involves tracking biological parameters over time, aligning with the tracing aspect.

https://pubmed.ncbi.nlm.nih.gov/37161241/

Location Tracking vs. Status Monitoring
A key distinction is whether bio-cyber interfaces are used for physical location tracking, like GPS, or for status monitoring. Given the nanoscale nature of IoBNT devices, knowing the location within the body, such as ensuring a nanodevice is in the correct organ, is crucial for targeted therapies. Research suggests this is more about spatial awareness at a microscopic level rather than macroscopic location tracking, as seen in papers discussing in-body nanonetworks. Regardless, the capabilities are present and possible.

Securing Bio-Cyber Interface for the Internet of Bio-Nano Things using Particle Swarm Optimization and Artificial Neural Networks based parameter https://www.sciencedirect.com/science/article/abs/pii/S0010482521005011

Luciferase Biosensors

Luciferase Biosensors for COVID-19 are virion organisms that can be found in the Swabs and Inoculations. In this video, These sensors are part of the Intra-Body Nano-network. Luciferase Biosensors have many other embodiments, properties, and functions that are NOT mentioned in this video.

https://x.com/byrdturd86/status/1909740354514890767?s=46

Nanoparticles are the gateway to the conversion/transmutation into Synthetic biology

Synthetic biology has transformed medicine through personalized therapies. Imagine engineered bacteria that live in your gut, detecting early signs of disease and releasing precise drugs tailored to your genetic makeup. Companies like Synlogic are already exploring this with "synthetic biotic medicines for metabolic disorders, and as gene-editing tools like CRISPR evolve, we’ll see more precise interventions. Think custom immune cells programmed to hunt down cancer with minimal side effects.

Agriculture is experiencing a radical shift too. Synthetic organisms might enhance crop resilience, reducing reliance on pesticides or fertilizers (which are synthetic). Plants engineered to fix their own nitrogen or withstand extreme climates. The development of lab-grown meat, and foods are steering us in a future where food production is less resource-intensive and more sustainable.